N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
• CAS No.: 1424328-93-7
• Molecular Formula: C₂₀H₁₆F₄N₆
• Molecular Weight: 416.381

Synonyms:N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property of N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

There total 6 articles about N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-{4-[(3-trifluoromethyl,4-fluorophenyl)amino]-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethylpropanamide (1424329-11-2) → N4-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1424328-93-7)

Guidance literature:

In methanol; at 70 ℃; for 10h;

DOI:10.1016/j.bmc.2012.12.045

Reference yield:

2,2-dimethyl-N-[4-oxo-6-(pyridin-2-ylethynyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]propanamide (479546-80-0) → N4-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1424328-93-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 5%-palladium/activated carbon; ammonium hydroxide; hydrogen / N,N-dimethyl-formamide; tetrahydrofuran / 24 h / 2585.81 Torr

2: trichlorophosphate / 3 h / Reflux

3: hydrogenchloride / isopropyl alcohol; water / 3 h / Reflux

4: methanol / 10 h / 70 °C

With hydrogenchloride; ammonium hydroxide; 5%-palladium/activated carbon; hydrogen; trichlorophosphate; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.12.045

Reference yield:

2,2-dimethyl-N-[4-oxo-6-(2-pyridin-2-ylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]propanamide (479546-87-7) → N4-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1424328-93-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / Reflux

2: hydrogenchloride / isopropyl alcohol; water / 3 h / Reflux

3: methanol / 10 h / 70 °C

With hydrogenchloride; trichlorophosphate; In methanol; water; isopropyl alcohol;

DOI:10.1016/j.bmc.2012.12.045

upstream raw materials:

2,2-dimethyl-N-[4-oxo-6-(pyridin-2-ylethynyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]propanamide

2,2-dimethyl-N-[4-oxo-6-(2-pyridin-2-ylethyl)-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-2-yl]propanamide

N-[4-chloro-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]-2,2-dimethylpropanamide

N-{4-[(3-trifluoromethyl,4-fluorophenyl)amino]-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl}-2,2-dimethylpropanamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1424328-93-7 N⁴-(3-trifluoromethyl-4-fluorophenyl)-6-(2-pyridin-2-yl-ethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send