1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

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Chemical Name:1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea
CAS No.:1263874-52-7
Molecular Formula:C₂₂H₂₃F₃N₆O₂S
Molecular Weight:492.525
Hs Code.:

Synonyms:1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

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Chemical Property of 1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

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Technology Process of 1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

There total 6 articles about 1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1263874-86-7
1-[4-(4-aminothiazol-2-yl)piperidin-1-yl]-2-(5-methyl-3-trifluoromethylpyrazol-1-yl)ethanone

: 103-71-9
phenyl isocyanate

: 1263874-52-7
1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 345637-71-0
(5-methyl-3-trifluoromethylpyrazol-1-yl)acetic acid

: 1263874-52-7
1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

2.2: pH 2 - 3

3.1: triethylamine / 0.5 h / 20 °C

3.2: 0.25 h / 100 °C / Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

4.2: 0.5 h / 20 °C

5.1: tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; water; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; 3.2: Curtius Rearrangement;

Reference yield:

: 922516-44-7
2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazole-4-carboxylic acid

: 1263874-52-7
1-(2-{1-[2-(5-methyl-3-trifluoromethyl-pyrazol-1-yl)-acetyl]-piperidin-4-yl}-thiazol-4-yl)-3-phenyl-urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 0.5 h / 20 °C

1.2: 0.25 h / 100 °C / Microwave irradiation

2.1: hydrogenchloride / 1,4-dioxane / 48 h / 20 °C

2.2: 0.5 h / 20 °C

3.1: tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; 1.2: Curtius Rearrangement;