(1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

Base Information

Chemical Name:(1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine
CAS No.:1611441-24-7
Molecular Formula:C₁₈H₁₆Cl₂N₂O₂S
Molecular Weight:395.309
Hs Code.:

Synonyms:(1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

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Chemical Property of (1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

Chemical Property:

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Technology Process of (1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

There total 5 articles about (1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1611441-16-7
C₂₆H₁₈Cl₂N₂O₄S

: 1611441-24-7
(1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;
DOI:10.1016/j.cclet.2014.03.047

Reference yield:

: 68769-69-7
2-((1H-indol-3-yl)methyl)isoindoline-1,3-dione

: 1611441-24-7
(1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridinium hydrobromide perbromide / tetrahydrofuran; chloroform / 3 h / -10 °C

2.1: lithium chloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 4 h / 100 °C / Inert atmosphere

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 0 - 20 °C / Inert atmosphere

4.1: hydrazine hydrate / ethanol / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium hydrobromide perbromide; sodium hydride; sodium carbonate; hydrazine hydrate; lithium chloride; In tetrahydrofuran; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene; mineral oil; 2.1: |Suzuki Coupling;
DOI:10.1016/j.cclet.2014.03.047

Reference yield:

: 1611441-11-2
2-((2-bromo-1H-indol-3-yl)methyl)isoindoline-1,3-dione

: 1611441-24-7
(1-(cyclopropylsulfonyl)-2-(2,4-dichlorophenyl)-1H-indol-3-yl)methanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium chloride; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 4 h / 100 °C / Inert atmosphere

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 1 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; hydrazine hydrate; lithium chloride; In ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 1.1: |Suzuki Coupling;
DOI:10.1016/j.cclet.2014.03.047