Technology Process of cyclohexane-2,2,6,6-d4-carboxylic acid
There total 7 articles about cyclohexane-2,2,6,6-d4-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
chromium(VI) oxide; sulfuric acid; water;
at 0 ℃;
DOI:10.1021/ja00392a031
- Guidance literature:
-
Multi-step reaction with 3 steps
1: NaHSO3, KCN / 2 h / 25 °C
2: 2 g / glacial acetic acid, conc. HCl / 3 h / Heating
3: FSO3H / liquid sulphur dioxide / 1.) -70 deg c, 2.) to -10 deg C then 0 deg C
With
hydrogenchloride; potassium cyanide; fluorosulphonic acid; sodium hydrogensulfite; acetic acid;
In
liquid sulphur dioxide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 82 percent / Na, D2O / 120 h
2: NaHSO3, KCN / 2 h / 25 °C
3: 2 g / glacial acetic acid, conc. HCl / 3 h / Heating
4: FSO3H / liquid sulphur dioxide / 1.) -70 deg c, 2.) to -10 deg C then 0 deg C
With
hydrogenchloride; potassium cyanide; water-d2; fluorosulphonic acid; sodium; sodium hydrogensulfite; acetic acid;
In
liquid sulphur dioxide;
