threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride

Base Information

• Chemical Name: threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride
• CAS No.: 914616-06-1
• Molecular Formula: C₉H₁₁NO₃*ClH
• Molecular Weight: 217.652
• Mol file: 914616-06-1.mol

Synonyms:threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride

Chemical Property of threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride

There total 2 articles about threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-3-phenyl-propionic acid (487060-76-4,487060-72-0) → threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride (914616-06-1)

Guidance literature:

With piperidine; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jo0303113

Reference yield:

threo-(2RS,3SR)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride → threo-(2R,3S)-2-amino-3-hydroxy-3-phenylpropanoic acid hydrochloride (914616-06-1)

Guidance literature:

optical resolution by replacing crystallization with Phe-OMe*HCl or preferential crystallization, then with n-PrOH;

DOI:10.1248/cpb.54.1170

upstream raw materials:

(2R,3S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-hydroxy-3-phenyl-propionic acid