2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

Base Information

Chemical Name:2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride
CAS No.:1402599-00-1
Molecular Formula:C₂₃H₁₅ClF₆N₂OS*ClH
Molecular Weight:553.355
Hs Code.:

Synonyms:2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

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Chemical Property of 2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

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Technology Process of 2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

There total 4 articles about 2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402599-06-7
(S)-N-((R)-(2-chlorophenyl)(7-(4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)-2-pyridinyl)-1-benzothiophen-2-yl)methyl)-2-methyl-2-propanesulfinamide

: 1402599-00-1
2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; at 20 ℃; for 5h;

Reference yield:

: 1402599-02-3
2-(2-chloro-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 1402599-00-1
2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 7 h / 80 °C

2.1: n-butyllithium / toluene; tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 °C

3.1: hydrogenchloride / diethyl ether / 5 h / 20 °C

With hydrogenchloride; n-butyllithium; sodium carbonate monohydrate; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; diethyl ether; water; toluene;

Reference yield:

: 65287-34-5
2-chloropyridine-4-carbonyl chloride

: 1402599-00-1
2-(2-(2-((R)-amino(2-chlorophenyl)methyl)-1-benzothiophen-7-yl)-4-pyridinyl)-1,1,1,3,3,3-hexafluoro-2-propanol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetramethylammonium fluoride / 1,2-dimethoxyethane / 21 h / -78 - 20 °C

1.2: 0 °C

2.1: XPhos; sodium carbonate monohydrate / bis(η3-allyl-μ-chloropalladium(II)) / 1,4-dioxane; water / 7 h / 80 °C

3.1: n-butyllithium / toluene; tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 °C

4.1: hydrogenchloride / diethyl ether / 5 h / 20 °C

With hydrogenchloride; n-butyllithium; sodium carbonate monohydrate; tetramethylammonium fluoride; XPhos; bis(η3-allyl-μ-chloropalladium(II)); In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; diethyl ether; water; toluene;