2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt

Base Information

• Chemical Name: 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt
• CAS No.: 1036647-85-4
• Molecular Formula: C₂₂H₂₀FN₄O₄*Na
• Molecular Weight: 446.413
• Mol file: 1036647-85-4.mol

Synonyms:2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt

Chemical Property of 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt

There total 4 articles about 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

C23H23FN4O6S (1036647-87-6) → 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt (1036647-85-4)

Guidance literature:

With sodium hydroxide; In methanol; at 20 ℃; for 1h;

Reference yield:

C22H23FN4O5 (1036647-86-5) → 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt (1036647-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h

2: sodium hydroxide / methanol / 1 h / 20 °C

With sodium hydroxide; triethylamine; In methanol; dichloromethane;

Reference yield:

2-amino-3-(4-fluorophenyl)propan-1-ol (35373-69-4,200267-65-8,348619-91-0,64230-78-0) → 2-[4-(4-fluoro-benzyl)-4,5-dihydro-oxazol-2-yl]-3-hydroxy-7-morpholin-4-yl-pyrido[1,2-a]pyrimidin-4-one sodium salt (1036647-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 48 h / Heating / reflux

2: triethylamine / dichloromethane / 2 h

3: sodium hydroxide / methanol / 1 h / 20 °C

With sodium hydroxide; triethylamine; In methanol; ethanol; dichloromethane;

upstream raw materials:

C₂₃H₂₃FN₄O₆S

3-hydroxy-7-morpholin-4-yl-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid methyl ester

C₂₂H₂₃FN₄O₅

2-amino-3-(4-fluorophenyl)propan-1-ol