Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Base Information

Chemical Name:Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester
CAS No.:378185-87-6
Molecular Formula:C₃₂H₃₉NO₆
Molecular Weight:533.665
Hs Code.:

Synonyms:Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Suppliers and Price of Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

There total 8 articles about Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1521-51-3,113667-32-6
rac-3-bromocyclohexene

: 332186-73-9
(4S)-4-Benzyl-3-[3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)propanoyl]-1,3-oxazolan-2-one

: 378185-87-6
Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Guidance literature:: (4S)-4-Benzyl-3-[3-(4-tert-butoxycarbonyloxy-2,6-dimethylphenyl)propanoyl]-1,3-oxazolan-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

rac-3-bromocyclohexene; In tetrahydrofuran; at -78 - -25 ℃;
DOI:10.1055/s-2001-16757

Reference yield:

: 80826-86-4
4-iodo-3,5-dimethylphenol

: 378185-87-6
Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 98 percent / Et₃N; DMAP / H₂O; tetrahydrofuran / 0.5 h / 20 °C

2.1: 61 percent / (o-MePh)3P; Et₃N / Pd(OAc)2 / acetonitrile / 24 h / Heating

3.1: H₂ / 10 percent Pd/C / ethyl acetate / 5 h / 60 °C / 3620.04 Torr

4.1: aq. NaOH / tetrahydrofuran / 20 °C

5.1: Et₃N / diethyl ether / 1 h / 0 °C

6.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

6.2: 81 percent / tetrahydrofuran; diethyl ether; hexane / 0.75 h / -78 - 0 °C

7.1: NaHMDS / tetrahydrofuran / -78 °C

7.2: 15 percent / tetrahydrofuran / -78 - -25 °C

With dmap; sodium hydroxide; n-butyllithium; hydrogen; sodium hexamethyldisilazane; triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; hexane; water; ethyl acetate; acetonitrile; 2.1: Heck coupling;
DOI:10.1055/s-2001-16757

Reference yield:

: 108-68-9,50356-23-5
3,5-Dimethylphenol

: 378185-87-6
Carbonic acid 4-[(R)-3-((S)-4-benzyl-2-oxo-oxazolidin-3-yl)-2-cyclohex-2-enyl-3-oxo-propyl]-3,5-dimethyl-phenyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 79 percent / KI; KIO₃; HCl / methanol

2.1: 98 percent / Et₃N; DMAP / H₂O; tetrahydrofuran / 0.5 h / 20 °C

3.1: 61 percent / (o-MePh)3P; Et₃N / Pd(OAc)2 / acetonitrile / 24 h / Heating

4.1: H₂ / 10 percent Pd/C / ethyl acetate / 5 h / 60 °C / 3620.04 Torr

5.1: aq. NaOH / tetrahydrofuran / 20 °C

6.1: Et₃N / diethyl ether / 1 h / 0 °C

7.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C

7.2: 81 percent / tetrahydrofuran; diethyl ether; hexane / 0.75 h / -78 - 0 °C

8.1: NaHMDS / tetrahydrofuran / -78 °C

8.2: 15 percent / tetrahydrofuran / -78 - -25 °C

With hydrogenchloride; dmap; potassium iodate; sodium hydroxide; n-butyllithium; hydrogen; sodium hexamethyldisilazane; triethylamine; tris-(o-tolyl)phosphine; potassium iodide; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; hexane; water; ethyl acetate; acetonitrile; 3.1: Heck coupling;
DOI:10.1055/s-2001-16757