(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Base Information

Chemical Name:(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate
CAS No.:1423046-46-1
Molecular Formula:C₃₅H₄₆F₃NO₅Si
Molecular Weight:645.835
Hs Code.:

(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Synonyms:(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Suppliers and Price of (3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

There total 10 articles about (3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1423046-38-1
(3R,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-9-hydroxy-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]

: 1423046-46-1
(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Guidance literature:: (3R,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-9-hydroxy-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 18h;

With acetic anhydride; at 130 ℃; for 2h;

Reference yield: 49.0%

: 1423046-38-1
(3R,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-9-hydroxy-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]

: 108-24-7
acetic anhydride

: 1423046-46-1
(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Guidance literature:: (3R,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-9-hydroxy-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2',3',5',6,6',7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4'-pyran]; With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 18h;

acetic anhydride; at 130 ℃; for 2h;

Reference yield:

: 1423046-30-3
7-hydroxyspiro[2.5]oct-6-en-5-one

: 1423046-46-1
(3R,6RS,9S)-9-(tert-butyldimethylsilyloxy)-4-isopropyl-7,7-(ethan-1,2-diyl)-3-(4-(trifluoromethyl)phenyl)-2′,3′,5′,6,6′,7,8,9-octahydro-3H-spiro[furo[3,4-c]quinoline-1,4′-pyran]-6-yl acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: ammonium acetate; acetic acid / toluene / 4 h / Dean-Stark; Reflux

2.1: 0.17 h / 200 °C / 15 Torr

2.2: 4 h

3.1: (1R,2S)-1-Amino-2-indanol; borane Ν,Ν-diethylaniline complex / tetrahydrofuran / 27 h / 0 - 20 °C

3.2: 0.5 h

4.1: 2,6-dimethylpyridine / tetrahydrofuran / 1 h

5.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.75 h / -78 °C

6.1: titanium tetrachloride; sodium tris(acetoxy)borohydride / dichloromethane / 2.5 h / 0 - 20 °C

7.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h

7.2: 2 h / 130 °C

With 2,6-dimethylpyridine; borane Ν,Ν-diethylaniline complex; (1R,2S)-1-Amino-2-indanol; ammonium acetate; tert.-butyl lithium; titanium tetrachloride; sodium tris(acetoxy)borohydride; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; pentane;