(+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

Base Information

Chemical Name:(+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate
CAS No.:904916-23-0
Molecular Formula:C₃₆H₃₂Cl₂N₂O₄S₂
Molecular Weight:691.699
Hs Code.:

Synonyms:(+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

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Chemical Property of (+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

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Technology Process of (+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

There total 6 articles about (+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 904916-17-2
(+/-)-4-chloro-N-(3-chloro-3-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)benzenesulfonamide

: 155172-15-9
4-(2-mercaptopropyl)benzoic acid methyl ester

: 904916-23-0
(+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

Guidance literature:: With N,N'-dimethylimidazolinone; caesium carbonate; at 40 ℃; for 12h;
DOI:10.1248/cpb.54.603

Reference yield:

: 203940-08-3
1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propenone

: 904916-23-0
(+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / potassium tert-butoxide / dioxane; benzene / 10 h / 80 °C

2: 90 percent / sodium borohydride / tetrahydrofuran; ethanol / 1 h / 20 °C

3: 100 percent / thionyl chloride / 1,2-dichloro-ethane / 5 h / 20 °C

4: 49 percent / cesium carbonate; N,N'-dimethylimidazolinone / 12 h / 40 °C

With sodium tetrahydroborate; thionyl chloride; N,N'-dimethylimidazolinone; potassium tert-butylate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; 1,2-dichloro-ethane; benzene; 1: Michael addition;
DOI:10.1248/cpb.54.603

Reference yield:

: 203940-38-9
(+/-)-4-chloro-N-(3-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}-3-hydroxypropyl)benzenesulfonamide

: 904916-23-0
(+/-) methyl 4-{2-[(3-{4-chlorophenylsulfonylamino}-1-{3-[(E)-2-(7-chloro-2-quinolyl)vinyl]phenyl}propyl)thio]ethyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / thionyl chloride / 1,2-dichloro-ethane / 5 h / 20 °C

2: 49 percent / cesium carbonate; N,N'-dimethylimidazolinone / 12 h / 40 °C

With thionyl chloride; N,N'-dimethylimidazolinone; caesium carbonate; In 1,2-dichloro-ethane;
DOI:10.1248/cpb.54.603