pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

Base Information

Chemical Name:pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide
CAS No.:1356015-56-9
Molecular Formula:C₁₇H₁₆N₄O₃
Molecular Weight:324.339
Hs Code.:

Synonyms:pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

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Chemical Property of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

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Technology Process of pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

There total 4 articles about pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356016-37-9
(E)-3-(3-amino-4-methoxy-phenyl)-prop-2-en-1-ol

: 25940-35-6
pyrazolo[1,5-a] pyrimidine-3-carboxylic acid

: 1356015-56-9
pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 80 ℃;

Reference yield:

: 31680-08-7
4-methoxy-3-nitrobenzaldehyde

: 1356015-56-9
pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / Reflux

2: zinc; acetic acid / dichloromethane / 0.5 h / 20 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 80 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 118509-98-1
(E)-methyl 3-(4-methoxy-3-nitrophenyl)acrylate

: 1356015-56-9
pyrazolo[1,5-a]pyrimidine-3-carboxylic acid [5-((E)-3-hydroxypropenyl)-2-methoxyphenyl]amide

Guidance literature:: Multi-step reaction with 3 steps

1: zinc; acetic acid / dichloromethane / 0.5 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.25 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / acetonitrile / 80 °C

With lithium aluminium tetrahydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; dichloromethane; acetonitrile;