2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-3-YL)METHYLENE)MALONONITRILE

Base Information

• Chemical Name: 2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-3-YL)METHYLENE)MALONONITRILE
• CAS No.: 477848-99-0
• Molecular Formula: C₁₉H₁₃N₃O₂S
• Molecular Weight: 347.397
• Mol file: 477848-99-0.mol

Synonyms:2-((1-tosyl-1H-indol-3-yl)methylene)malononitrile

Chemical Property of 2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-3-YL)METHYLENE)MALONONITRILE

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

2-((1-((4-METHYLPHENYL)SULFONYL)-1H-INDOL-3-YL)METHYLENE)MALONONITRILE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-3-YL)METHYLENE)MALONONITRILE

There total 3 articles about 2-((1-[(4-METHYLPHENYL)SULFONYL]-1H-INDOL-3-YL)METHYLENE)MALONONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

1-(4-tolylsulfonyl)indole-3-carboxaldehyde (50562-79-3) + malononitrile (109-77-3) → 2-((1-tosyl-1H-indol-3-yl)methylene)malononitrile (477848-99-0)

Guidance literature:

With sodium hydroxide; In ethanol; water; at 20 ℃;

DOI:10.1002/chem.201103009

Reference yield:

Indole-3-carboxaldehyde (487-89-8,1228547-52-1) → 2-((1-tosyl-1H-indol-3-yl)methylene)malononitrile (477848-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium hydroxide / ethanol; water / 20 °C

With triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1002/chem.201103009

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 2-((1-tosyl-1H-indol-3-yl)methylene)malononitrile (477848-99-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C

2: sodium hydroxide / ethanol; water / 20 °C

With triethylamine; sodium hydroxide; In ethanol; dichloromethane; water;

DOI:10.1002/chem.201103009

upstream raw materials:

1-(4-tolylsulfonyl)indole-3-carboxaldehyde

malononitrile

Indole-3-carboxaldehyde

p-toluenesulfonyl chloride