4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester>

Base Information

• Chemical Name: 4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester>
• CAS No.: 73102-78-0
• Molecular Formula: C₃₁H₂₈O₅S
• Molecular Weight: 512.626
• Mol file: 73102-78-0.mol

Synonyms:4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester>

Chemical Property of 4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester>

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester>

There total 2 articles about 4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-[(methylsulfanyl)methyl]benzoate (67003-49-0) → 4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester> (73102-78-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) 1,6 M butyllithium / 1) THF, hexane, -78 deg C, 2) -78 deg C, 7h; 20 deg C, 2h

2: 1) 2,2 M BuLi / 1) THF, hexane, 2) 1,2-dimethoxyethane, 1h, 25 deg C

With n-butyllithium;

DOI:10.1002/jlac.198219820116

Reference yield:

2<4-Methylthiomethylphenyl>-2-oxoethylphosphonsaeure-dimethylester (73102-75-7) + Biphenyl-4-carboxylic acid (3aS,5S,6aR)-4-formyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester (38754-71-1,39265-58-2,39648-29-8,40667-54-7,42586-63-0,51642-99-0,52522-09-5) → 4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester> (73102-78-0)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, 2) 1,2-dimethoxyethane, 1h, 25 deg C;

DOI:10.1002/jlac.198219820116

Reference yield: 31.0%

4-Biphenylcarbonsaeure-<6-<(4-methylthiomethylphenyl)carbonylvinyl>-3-oxo-2-oxa-7-bicyclo-<3.3.0>octylester> (73102-78-0) → 4-Biphenylcarbonsaeure-<6-<3-hydroxy-3-(4-methylthiomethylphenyl)-1-propenyl>-3-oxo-2-oxa-7-bicyclo<3.3.0>octylester> (73102-79-1,73174-20-6)

Guidance literature:

With aluminum isopropoxide; In toluene; at 80 ℃; for 6h;

DOI:10.1002/jlac.198219820116

upstream raw materials:

2<4-Methylthiomethylphenyl>-2-oxoethylphosphonsaeure-dimethylester

Biphenyl-4-carboxylic acid (3aS,5S,6aR)-4-formyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

methyl 4-[(methylsulfanyl)methyl]benzoate

Downstream raw materials:

4-Biphenylcarbonsaeure-<6-<3-hydroxy-3-(4-methylthiomethylphenyl)-1-propenyl>-3-oxo-2-oxa-7-bicyclo<3.3.0>octylester>

7-Hydroxy-6-<3-hydroxy-3-(4-methylthiomethylphenyl)-1-propenyl>-2-oxabicyclo<3.3.0>octan-3-on

(5Z,9α,11α,13E)-9,11,13-Trihydroxy-15-(4-methylthiomethylphenyl)-16,17,18,19,20-pentaprosta-5,14-dien-1-saeure

(3aS,5S,6aR)-4-[(E)-3-(4-Methylsulfanylmethyl-phenyl)-3-(tetrahydro-pyran-2-yloxy)-propenyl]-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-2-ol