methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

Base Information

Chemical Name:methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate
CAS No.:230973-50-9
Molecular Formula:C₂₈H₂₉NO₃
Molecular Weight:427.543
Hs Code.:

Synonyms:methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

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Chemical Property of methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

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Technology Process of methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

There total 4 articles about methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 230973-49-6
dimethyl-N^α-(9-phenylfluoren-9-yl)-3,3-dimethyl-γ,δ-dehydro-D-homoglutamate

: 230973-50-9
methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

Guidance literature:: With diisobutylaluminium hydride; In hexane; dichloromethane; at -45 ℃; for 0.25h;
DOI:10.1021/jo982474a

Reference yield:

: 230973-48-5
(2R)-3,3-dimethyl-4-oxo-2-<(9-phenylfluoren-9-yl)amino>butyric acid methyl ester

: 230973-50-9
methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DME, 0 deg C, 15 min, 2.) DME, room temperature, 3 h

2: 93 percent / DIBAL-H / CH₂Cl₂; hexane / 0.25 h / -45 °C

With sodium hydride; diisobutylaluminium hydride; In hexane; dichloromethane;
DOI:10.1021/jo982474a

Reference yield:

: 230973-45-2
dimethyl-N^α-(9-phenylfluoren-9-yl)-3,3-dimethyl-D-aspartate

: 230973-50-9
methyl-(2R)-3,3-dimethyl-6-hydroxy-2-<(9-phenylfluoren-9-yl)amino>-4-hexenoate

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / DIBAL-H / CH₂Cl₂; hexane / 3 h / -40 °C

2: Dess-Martin periodinane / 2 h / Ambient temperature

3: 1.) NaH / 1.) DME, 0 deg C, 15 min, 2.) DME, room temperature, 3 h

4: 93 percent / DIBAL-H / CH₂Cl₂; hexane / 0.25 h / -45 °C

With sodium hydride; diisobutylaluminium hydride; Dess-Martin periodane; In hexane; dichloromethane;
DOI:10.1021/jo982474a