1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid

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Chemical Name:1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid
CAS No.:1185854-75-4
Molecular Formula:C₁₃H₁₄N₂O₅
Molecular Weight:278.265
Hs Code.:

Synonyms:1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid

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Chemical Property of 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid

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Technology Process of 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid

There total 2 articles about 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1185854-66-3
6-methyl-4-(2-benzyloxy-4-methoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid benzyl ester

: 1185854-75-4
1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid

Guidance literature:: With 10% palladium on activated carbon; ammonium formate; In methanol; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2009.05.088

Reference yield:

: 32884-23-4
2-benzyloxy-4-methoxybenzaldehyde

: 1185854-75-4
1,2,3,4-tetrahydro-6-methyl-2-oxo-4-(4-methoxy-2-hydroxyphenyl)-pyrimidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 16 h / Reflux

2: 10% palladium on activated carbon; ammonium formate / methanol / 4 h / 20 °C

With 10% palladium on activated carbon; ammonium formate; scandium tris(trifluoromethanesulfonate); In methanol; acetonitrile; 1: Biginelli pyrimidine synthesis;
DOI:10.1016/j.tet.2009.05.088