5-fluoro-2,4-diphenylthiazole

Base Information

Chemical Name:5-fluoro-2,4-diphenylthiazole
CAS No.:951000-48-9
Molecular Formula:C₁₅H₁₀FNS
Molecular Weight:255.316
Hs Code.:

Synonyms:5-fluoro-2,4-diphenylthiazole

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Chemical Property of 5-fluoro-2,4-diphenylthiazole

Chemical Property:

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Technology Process of 5-fluoro-2,4-diphenylthiazole

There total 4 articles about 5-fluoro-2,4-diphenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 35342-50-8
5-bromo-2,4-diphenylthiazole

: 951000-48-9
5-fluoro-2,4-diphenylthiazole

Guidance literature:: 5-bromo-2,4-diphenylthiazole; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; diethyl ether; hexane; at -78 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.organomet.5b00631

Reference yield: 43.0%

: 1826-14-8
2,4-diphenylthiazole

: 951000-48-9
5-fluoro-2,4-diphenylthiazole

Guidance literature:: With Accufluor(R); In acetonitrile; at 60 ℃;
DOI:10.1016/j.jfluchem.2006.08.007

Reference yield:

: 98-80-6
phenylboronic acid

: 951000-48-9
5-fluoro-2,4-diphenylthiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium phosphate / tetrahydrofuran; water / 12 h / 60 °C / Schlenk technique; Sealed tube; Inert atmosphere

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 12 h / 40 °C

3.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; n-butyllithium; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide; 1.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/acs.organomet.5b00631