8(R)-Hete

Base Information

Chemical Name:8(R)-Hete
CAS No.:105500-09-2
Molecular Formula:C₂₀H₃₂O₃
Molecular Weight:320.472
Hs Code.:
DSSTox Substance ID:DTXSID501318647
Nikkaji Number:J867.978I
Wikidata:Q27116102
Metabolomics Workbench ID:2644
Mol file:105500-09-2.mol

Synonyms:8(R)-HETE;105500-09-2;8(R)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid;8R-HETE;(5Z,8R,9E,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid;8R-hydroxy-5Z,9E,11Z,14Z-eicosatetraenoic acid;(5Z,9E,11Z,14Z)-(8R)-8-Hydroxyeicosa-5,9,11,14-tetraenoic acid;(5Z,9E,11Z,14Z)-(8R)-8-Hydroxyicosa-5,9,11,14-tetraenoic acid;5,9,11,14-Eicosatetraenoicacid, 8-hydroxy-, (5Z,8R,9E,11Z,14Z)-;SCHEMBL8509405;CHEBI:34484;8(R)-hydroxyeicosatetraenoic acid;DTXSID501318647;LMFA03060021;J-001439;Q27116102;(8R)-hydroxy-(5Z),(9E),(11Z),(14Z)-eicosatetraenoic acid;(R)-(Z,E,Z,Z)-8-hydroxyeicosa-5,9,11,14-tetraenoic acid;8(R)-hydroxy-5(Z),9(E),11(Z),14(Z)-eicosatetraenoic acid;(5Z,8R,9E,11Z,14Z)-8-hydroxyeicosa-5,9,11,14-tetraenoic acid;(5Z,9E,11Z,14Z)-(8R)-8-Hydroxyeicosa-5,9,11,14-tetraenoate;(5Z,9E,11Z,14Z)-(8R)-8-Hydroxyicosa-5,9,11,14-tetraenoate;(+)-(8R,5Z,9E,11Z,14Z)-8-hydroxy-5,9,11,14-eicosatetraenoic acid;(+)-(8R,5Z,9E,11Z,14Z)-8-hydroxy-5,9,11,14-icosatetraenoic acid;8(R)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoic acid, ~100 mug/mL in ethanol, ~98%

Suppliers and Price of 8(R)-Hete

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
8(R)-HETE ≥98%
100μg
$ 432.00

Cayman Chemical
8(R)-HETE ≥98%
50μg
$ 228.00

Cayman Chemical
8(R)-HETE ≥98%
25μg
$ 120.00

American Custom Chemicals Corporation
8(R)-HYDROXY-(5Z,9E,11Z,14Z)-EICOSATETRAENOIC ACID 95.00%
5MG
$ 495.06

AHH
8(R)-Hydroxy-(5Z,9E,11Z,14Z)-eicosatetraenoicacid 98%
0.00025g
$ 518.00

Total 2 raw suppliers

Chemical Property of 8(R)-Hete

Chemical Property:

Vapor Pressure:7.45E-11mmHg at 25°C
Refractive Index:1.513
Boiling Point:471.1°C at 760 mmHg
PKA:4.75±0.10(Predicted)
Flash Point:252.8°C
PSA：57.53000
Density:0.984g/cm³
LogP:5.18750
Storage Temp.:−20°C
XLogP3:5.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:14
Exact Mass:320.23514488
Heavy Atom Count:23
Complexity:392

Purity/Quality:

98% ^*data from raw suppliers

8(R)-HETE ≥98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:F,Xi
Statements: 11-36/37/38
Safety Statements: 16-26-36-7

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCC=CCC=CC=CC(CC=CCCCC(=O)O)O
Isomeric SMILES:CCCCC/C=C\C/C=C\C=C\[C@@H](C/C=C\CCCC(=O)O)O

Technology Process of 8(R)-Hete

There total 4 articles about 8(R)-Hete which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 105500-09-2,79495-84-4
(8R)-hydroxyeicosatetraenoic acid

Guidance literature:: all cis 5,8,11,14-eicosatetraenoic acid; With 8R-lipoxygenase; sodium chloride; calcium chloride; In ethanol; at 20 ℃; pH=8; Enzymatic reaction;

With triphenylphosphine; In methanol; at 20 ℃; for 0.5h; Reagent/catalyst; Kinetics;
DOI:10.1074/jbc.M114.599662

Reference yield:

: 506-32-1,236743-58-1
all cis 5,8,11,14-eicosatetraenoic acid

: 54397-83-0,59985-28-3
12-hydroxyeicosatetraenoic acid

: 82337-46-0
(R)-12-HETE

: 98462-03-4,79495-84-4
8(S)-hydroxyeicosatetraenoic acid

: 105500-09-2,79495-84-4
(8R)-hydroxyeicosatetraenoic acid

: 73347-43-0,73804-65-6
(R)-11-hydroxy-eicosa-5,8,12,14-tetraenoic acid

: 54845-95-3,73945-47-8,83603-31-0
icomucret

: 73945-47-8,83603-31-0
15(R)-HETE

: 54886-50-9,73804-65-6
(S)-11-hydroxy-eicosa-5,8,12,14-tetraenoic acid

Guidance literature:: all cis 5,8,11,14-eicosatetraenoic acid; With 8R-lipoxygenase A₅₈₉M mutant; sodium chloride; calcium chloride; In ethanol; at 20 ℃; pH=8; Enzymatic reaction;

With triphenylphosphine; In methanol; at 20 ℃; for 0.5h; Reagent/catalyst; Kinetics;
DOI:10.1074/jbc.M114.599662