N-cyclopentyl-4-hydroxybenzamide

Base Information

• Chemical Name: N-cyclopentyl-4-hydroxybenzamide
• CAS No.: 1019403-15-6
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 1019403-15-6.mol

Synonyms:N-cyclopentyl-4-hydroxybenzamide

Chemical Property of N-cyclopentyl-4-hydroxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-cyclopentyl-4-hydroxybenzamide

There total 1 articles about N-cyclopentyl-4-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Cyclopentamine (1003-03-8) + 4-hydroxy-benzoic acid (99-96-7) → N-cyclopentyl-4-hydroxybenzamide (1019403-15-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetone; Heating;

DOI:10.1016/j.bmc.2020.115351

Reference yield:

N-cyclopentyl-4-hydroxybenzamide (1019403-15-6) + 2-amino-3,5-dibromopyrazine (24241-18-7) → C16H17BrN4O2

Guidance literature:

With 1-methyl-pyrrolidin-2-one; potassium carbonate; at 100 ℃; for 6h; Inert atmosphere;

DOI:10.1016/j.bmc.2020.115351

Reference yield:

N-cyclopentyl-4-hydroxybenzamide (1019403-15-6) → 4-((3-amino-6-(3,5-dimethylisoxazol-4-yl)pyrazin-2-yl)oxy)-N-cyclopentylbenzamide

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one; potassium carbonate / 6 h / 100 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

With 1-methyl-pyrrolidin-2-one; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate; potassium carbonate; In 1,4-dioxane; 2: |Suzuki Coupling;

DOI:10.1016/j.bmc.2020.115351

upstream raw materials:

Cyclopentamine

4-hydroxy-benzoic acid

Downstream raw materials:

C₁₆H₂₁FN₂O₂*ClH