5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Base Information

• Chemical Name: 5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene
• CAS No.: 1365254-49-4
• Molecular Formula: C₅₇H₇₃NO₅
• Molecular Weight: 852.21
• Mol file: 1365254-49-4.mol

Synonyms:5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Chemical Property of 5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene

There total 1 articles about 5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5,11,17,23-tetra-tert-butyl-25,26,27-trihydroxy-28-propoxy-calix<4>arene (135604-55-6) + bromo<(S)-(1-phenylethyl)carbamoyl>methane (193967-71-4) → 5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene (1365254-49-4)

Guidance literature:

5,11,17,23-tetra-tert-butyl-25,26,27-trihydroxy-28-propoxy-calix<4>arene; With potassium carbonate; In acetonitrile; at 70 ℃; for 1h; Inert atmosphere;

bromo<(S)-(1-phenylethyl)carbamoyl>methane; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1134/S1070428012020200

Reference yield: 92.0%

5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene (1365254-49-4) + p-toluenesulfonyl chloride (98-59-9) → 5,11,17,23-tetra(tert-butyl)-25-hydroxy-27-[(4-methylphenyl)sulfonyloxy]-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene

Guidance literature:

5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene; With pyridine; at 20 ℃; for 1h; Inert atmosphere;

p-toluenesulfonyl chloride; at 20 - 100 ℃; for 25.5h; optical yield given as %de; Inert atmosphere;

DOI:10.1134/S1070428012020200

Reference yield: 48.0%

5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene (1365254-49-4) + N,N-Dimethylcarbamoyl chloride (79-44-7) → C63H83N3O7

Guidance literature:

5,11,17,23-tetra(tert-butyl)-25,27-dihydroxy-28-propoxy-26-[N-(1-phenylethyl)carbamoylmethoxy]calix[4]arene; With potassium tert-butylate; In 1,4-dioxane; at 20 ℃; for 0.5h; under 760.051 Torr;

N,N-Dimethylcarbamoyl chloride; In 1,4-dioxane; at 100 ℃; for 20h; under 760.051 Torr;

DOI:10.1021/acs.joc.6b01682

upstream raw materials:

5,11,17,23-tetra-tert-butyl-25,26,27-trihydroxy-28-propoxy-calix<4>arene

bromo<(S)-(1-phenylethyl)carbamoyl>methane