(2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

Base Information

Chemical Name:(2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol
CAS No.:157837-40-6
Molecular Formula:C₂₁H₄₃IO₃Si
Molecular Weight:498.561
Hs Code.:

Synonyms:(2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

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Chemical Property of (2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

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Technology Process of (2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

There total 5 articles about (2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 143619-00-5
Triisopropyl-[(1R,2R,4S)-2-methoxy-4-((R)-(R)-2-oxiranyl-propyl)-cyclohexyloxy]-silane

: 157837-40-6
(2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

Guidance literature:: With boron trifluoride diethyl etherate; lithium iodide; In diethyl ether; at -78 ℃;
DOI:10.1021/ja963066w

Reference yield:

: 127258-23-5
(1R,2R,4R)-4-<(phenylsulfonyl)methyl>-2-methoxy-1-<oxy>cyclohexane

: 157837-40-6
(2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi, 2.) BF₃*Et₂O, 3.) Na₂HPO₄, 4.) Na(Hg)

2: 92 percent / Et₃N

3: 87 percent / NaH / hexamethylphosphoric acid triamide / 6 h / Ambient temperature

4: 78 percent / LiI, BF₃*OEt₂ / diethyl ether / -78 °C

With disodium hydrogenphosphate; n-butyllithium; sodium amalgam; boron trifluoride diethyl etherate; sodium hydride; triethylamine; lithium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1021/ja963066w

Reference yield:

: 157837-32-6
(2S,3R)-1-(tert-Butyl-diphenyl-silanyloxy)-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

: 157837-40-6
(2R,3R)-1-Iodo-4-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-3-methyl-butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / Et₃N

2: 87 percent / NaH / hexamethylphosphoric acid triamide / 6 h / Ambient temperature

3: 78 percent / LiI, BF₃*OEt₂ / diethyl ether / -78 °C

With boron trifluoride diethyl etherate; sodium hydride; triethylamine; lithium iodide; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
DOI:10.1021/ja963066w