tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

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Chemical Name:tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate
CAS No.:872323-65-4
Molecular Formula:C₃₀H₂₉F₂N₃O₄
Molecular Weight:533.575
Hs Code.:

Synonyms:tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

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Chemical Property of tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

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Technology Process of tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

There total 4 articles about tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 5220-08-6
3-amino-4-(4-fluorophenyl)quinolin-2(1H)-one

: 218608-98-1,218608-99-2
(3R)-3-[(tert-butoxycarbonyl)amino]-4-(2-fluorophenyl)butanoic acid

: 872323-65-4
tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

Guidance literature:: With 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 872323-66-5
N-[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]acetamide

: 872323-65-4
tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid; acetic acid / 2 h / 150 °C

1.2: 0 °C / pH 9

2.1: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 20 °C

With 4-methyl-morpholine; sulfuric acid; acetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran;

Reference yield:

: 872323-67-6
N₂-acetyl-N₁-[2-(4-fluorobenzoyl)phenyl]glycinamide

: 872323-65-4
tert-butyl ((1R)-1-(2-fluorobenzyl)-3-{[4-(4-fluorophenyl)-2-oxo-1,2-dihydroquinolin-3-yl]amino}-3-oxopropyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / ethanol / 20 °C

2.1: sulfuric acid; acetic acid / 2 h / 150 °C

2.2: 0 °C / pH 9

3.1: 4-methyl-morpholine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride / tetrahydrofuran / 20 °C

With 4-methyl-morpholine; sulfuric acid; potassium tert-butylate; acetic acid; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In tetrahydrofuran; ethanol;