1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

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Chemical Name:1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea
CAS No.:512846-20-7
Molecular Formula:C₂₀H₁₈N₈O₃S
Molecular Weight:450.481
Hs Code.:

Synonyms:1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

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Chemical Property of 1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

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Technology Process of 1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

There total 8 articles about 1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 5416-93-3
4-Methoxyphenyl isocyanate

: 512846-10-5
2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

: 512846-20-7
1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

Guidance literature:: With triethylamine; In 1,4-dioxane; for 18h; Heating;
DOI:10.1021/jm021023m

Reference yield:

: 512845-98-6
3-amino-1H-1-methyl-5-methylsulfanyl-4-[3-(2-furyl)-1,2,4-triazol-5-yl]pyrazole

: 512846-20-7
1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / p-TsOH / 1-methyl-pyrrolidin-2-one / 22 h / 160 °C

2: 30 percent / Et₃N / dioxane / 18 h / Heating

With toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one;
DOI:10.1021/jm021023m

Reference yield:

: 5147-80-8
[Bis(methylthio)methylene]malononitrile

: 512846-20-7
1-(2-furan-2-yl-8-methyl-9-methylsulfanyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-3-(4-methoxy-phenyl)-urea

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / ethanol / 6 h / Heating

2: 94 percent / 12 h / Heating

3: 2-methoxy-ethanol / 12 h / Heating

4: diphenyl ether / 1.5 h / 260 °C

5: 84 percent / aq. HCl / dioxane / 1 h / Heating

6: 83 percent / p-TsOH / 1-methyl-pyrrolidin-2-one / 22 h / 160 °C

7: 30 percent / Et₃N / dioxane / 18 h / Heating

With hydrogenchloride; toluene-4-sulfonic acid; triethylamine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; diphenylether; ethanol; 2-methoxy-ethanol;
DOI:10.1021/jm021023m