N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

Base Information

Chemical Name:N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide
CAS No.:1092393-77-5
Molecular Formula:C₃₀H₂₅N₇O₃
Molecular Weight:531.574
Hs Code.:

Synonyms:N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

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Chemical Property of N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

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Technology Process of N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

There total 7 articles about N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 3222-47-7
6-methylnicotinic acid

: 1092395-11-3
N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide

: 1092393-77-5
N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

Guidance literature:: 6-methylnicotinic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; at 20 ℃; for 1h;

N-{3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}-3-(1-cyano-1-methylethyl)benzamide; With pyridine; at 20 ℃; for 168h;

Reference yield:

: 1092395-14-6
3-(1-cyanocyclopropyl)benzoyl chloride

: 1092393-77-5
N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 5 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C / 1520.1 Torr

4.1: dimethyl sulfoxide / 6 h / 20 °C

5.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 15 h / 60 °C

6.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

6.2: 168 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1092395-08-8
3-(1-cyano-1-methylethyl)-N-(3-hydroxy-4-methylphenyl)benzamide

: 1092393-77-5
N-{6-[5-({[3-(1-cyano-1-methylethyl)phenyl]carbonyl}amino)-2-methylphenoxy][1,2,4]triazolo[1,5-a]pyridin-2-yl}pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C / 1520.1 Torr

3.1: dimethyl sulfoxide / 6 h / 20 °C

4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol; ethanol / 15 h / 60 °C

5.1: oxalyl dichloride / N,N-dimethyl-formamide / tetrahydrofuran / 1 h / 20 °C

5.2: 168 h / 20 °C

With oxalyl dichloride; hydroxylamine hydrochloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide;