Octahydro-indolizine-6,7-diol

Base Information

Chemical Name:Octahydro-indolizine-6,7-diol
CAS No.:105343-56-4
Molecular Formula:C₈H₁₅NO₂
Molecular Weight:157.213
Hs Code.:
DSSTox Substance ID:DTXSID70552440
Mol file:105343-56-4.mol

Synonyms:OCTAHYDRO-INDOLIZINE-6,7-DIOL;105343-56-4;OCTAHYDROINDOLIZINE-6,7-DIOL;1,2,3,5,6,7,8,8a-octahydroindolizine-6,7-diol;DTXSID70552440;AKOS006288380

Suppliers and Price of Octahydro-indolizine-6,7-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
OCTAHYDRO-INDOLIZINE-6,7-DIOL 95.00%
5MG
$ 504.59

Total 2 raw suppliers

Chemical Property of Octahydro-indolizine-6,7-diol

Chemical Property:

Vapor Pressure:0.00028mmHg at 25°C
Refractive Index:1.572
Boiling Point:287.4°C at 760 mmHg
Flash Point:154.4°C
PSA：43.70000
Density:1.23g/cm³
LogP:-0.48580
XLogP3:-0.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:157.110278721
Heavy Atom Count:11
Complexity:151

Purity/Quality:

95% ^*data from raw suppliers

OCTAHYDRO-INDOLIZINE-6,7-DIOL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2CC(C(CN2C1)O)O

Technology Process of Octahydro-indolizine-6,7-diol

There total 4 articles about Octahydro-indolizine-6,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 115684-36-1
(6R,7S,8aR)-6,7-diacetoxy-indolizidine

: 115793-13-0,105343-56-4
(6R,7S,8aR)-6,7-dihydroxy-indolizidine

Guidance literature:: With sodium methylate; In methanol; for 1h;
DOI:10.1016/S0040-4020(01)89805-7

Reference yield:

: 115684-42-9
(3R,4S)-6-((E)-2-Ethoxycarbonyl-vinyl)-3,4-dihydroxy-3,4-dihydro-2H-pyridine-1-carboxylic acid benzyl ester

: 115793-13-0,105343-56-4
(6R,7S,8aR)-6,7-dihydroxy-indolizidine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethanol / 6 h / 2327.2 Torr

2: pyridine

3: 77 percent / borane-dimethylsulphide complex / tetrahydrofuran

4: 79 percent / sodium methoxide / methanol / 1 h

With dimethylsulfide borane complex; hydrogen; sodium methylate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; ethanol;
DOI:10.1016/S0040-4020(01)89805-7

Reference yield:

: 115793-17-4
2,3,4,5,8-pentadeoxy-4,8-amino-D-arabino-octono-1,4-lactam

: 115793-13-0,105343-56-4
(6R,7S,8aR)-6,7-dihydroxy-indolizidine

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine

2: 77 percent / borane-dimethylsulphide complex / tetrahydrofuran

3: 79 percent / sodium methoxide / methanol / 1 h

With dimethylsulfide borane complex; sodium methylate; In tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4020(01)89805-7