2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

Base Information

Chemical Name:2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate
CAS No.:1445865-16-6
Molecular Formula:C₃₁H₃₂ClN₅O₅
Molecular Weight:590.079
Hs Code.:

2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

Synonyms:2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

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Chemical Property of 2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

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Technology Process of 2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

There total 11 articles about 2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₃₂ClN₃O₈

: 1445865-16-6
2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

: 1445961-75-0
2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(4-{4-[(methoxycarbonyl)amino]phenyl}-5-methyl-1,3-oxazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

Guidance literature:: With ammonium acetate; In toluene; for 12h; Reflux;

Reference yield:

: 1445865-54-2
3-ethyl 8-methyl (3S)-7-hydroxy-5-oxo-1,2,3,5-tetrahydroindolizine-3,8-dicarboxylate

: 1445865-16-6
2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

: 1445961-75-0
2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(4-{4-[(methoxycarbonyl)amino]phenyl}-5-methyl-1,3-oxazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 9 steps

1: sodium hydroxide / 20 °C

2: hydrogenchloride; water / 20 h / 140 °C

3: sulfuric acid / 4 h / 100 °C

4: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

5: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

6: triethylamine; dmap / tetrahydrofuran / 2 h / 60 °C

7: sodium hydroxide; methanol / 48 h / 20 °C

8: potassium carbonate / acetonitrile / 8 h / 50 °C

9: ammonium acetate / toluene / 12 h / Reflux

With hydrogenchloride; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonium acetate; water; potassium carbonate; triethylamine; cesium fluoride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 7149-65-7
ethyl (S)-pyroglutamate

: 1445865-16-6
2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(5-{4-[(methoxycarbonyl)amino]phenyl}-4-methyl-1H-imidazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

: 1445961-75-0
2-methyl-2-propanyl {4-chloro-2-[(3S)-3-(4-{4-[(methoxycarbonyl)amino]phenyl}-5-methyl-1,3-oxazol-2-yl)-5-oxo-1,2,3,5-tetrahydro-7-indolizinyl]phenyl}carbamate

Guidance literature:: Multi-step reaction with 11 steps

1: dichloromethane / 3 h / 20 °C

2: triethylamine / 3 h / 120 °C

3: sodium hydroxide / 20 °C

4: hydrogenchloride; water / 20 h / 140 °C

5: sulfuric acid / 4 h / 100 °C

6: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

7: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

8: triethylamine; dmap / tetrahydrofuran / 2 h / 60 °C

9: sodium hydroxide; methanol / 48 h / 20 °C

10: potassium carbonate / acetonitrile / 8 h / 50 °C

11: ammonium acetate / toluene / 12 h / Reflux

With hydrogenchloride; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonium acetate; water; potassium carbonate; triethylamine; cesium fluoride; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;