benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1609468-21-4
Molecular Formula:C₃₁H₂₈ClN₅O₃S
Molecular Weight:586.114
Hs Code.:

Synonyms:benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 6 articles about benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609467-84-6
3-[5-acetylamino-4-cyano-3-(4-iodophenyl)-pyrazol-1-yl]piperidine-1-carboxylic acid benzyl ester

: 106-54-7
p-Chlorothiophenol

: 1609468-21-4
benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With 1-Methylpyrrolidine; copper(l) iodide; potassium carbonate; at 100 ℃;

Reference yield:

: 1609467-75-5
2-(hydroxy(4-iodophenyl)methylene)malononitrile

: 1609468-21-4
benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 16 h / 0 - 80 °C

2.1: triethylamine; 2-(methoxy(3-iodo)methylene)-malononitrile / ethanol / 16 h / 20 - 80 °C

3.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

4.1: copper(l) iodide; potassium carbonate; 1-Methylpyrrolidine / 100 °C

With 1-Methylpyrrolidine; copper(l) iodide; 2-(methoxy(3-iodo)methylene)-malononitrile; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 1609468-21-4
benzyl 3-(5-acetamido-3-(4-((4-chlorophenyl)thio)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

1.2: 16 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 16 h / 0 - 80 °C

3.1: triethylamine; 2-(methoxy(3-iodo)methylene)-malononitrile / ethanol / 16 h / 20 - 80 °C

4.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

5.1: copper(l) iodide; potassium carbonate; 1-Methylpyrrolidine / 100 °C

With 1-Methylpyrrolidine; copper(l) iodide; 2-(methoxy(3-iodo)methylene)-malononitrile; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane;