2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

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Chemical Name:2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione
CAS No.:1432112-27-0
Molecular Formula:C₂₇H₁₉ClN₆O₃
Molecular Weight:510.939
Hs Code.:

Synonyms:2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

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Chemical Property of 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

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Technology Process of 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

There total 8 articles about 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-08-8
cinchomeronic anhydride

: 1432112-24-7
2-chloro-N⁴-[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]benzene-1,4-diamine

: 1432112-27-0
2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

Guidance literature:: With acetic acid; at 110 ℃; for 20h;

Reference yield:

: 272-52-6
1H-pyrazolo-[4,3-b]-pyridine

: 1432112-27-0
2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / methanol; water / 0.67 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 4 h / Reflux; Inert atmosphere

4: hydrogenchloride / ethanol / 2 h / Reflux

5: acetic acid / 20 h / 110 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; potassium carbonate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 121-87-9
2-Chloro-4-nitroaniline

: 1432112-27-0
2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridin-3-yl]amino}phenyl)-1H-pyrrolo[3,4-c] pyridine-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; pyridine / 20 °C

2: hydrogenchloride; tin(II) chloride dihdyrate / 2 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 4 h / Reflux; Inert atmosphere

4: hydrogenchloride / ethanol / 2 h / Reflux

5: acetic acid / 20 h / 110 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tin(II) chloride dihdyrate; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; pyridine; ethanol; dichloromethane;