Technology Process of C13H14BrF3O2
There total 3 articles about C13H14BrF3O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
tetrahydrofuran;
at -78 ℃;
for 0.166667h;
Overall yield = 80 %;
DOI:10.1021/cs500667g
- Guidance literature:
-
Multi-step reaction with 3 steps
1: amine
2: (5aR,10bS)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; caesium carbonate / tetrahydrofuran / 16 h / 20 °C / Molecular sieve
3: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / -78 °C
With
(5aR,10bS)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; lithium aluminium tetrahydride; caesium carbonate;
In
tetrahydrofuran;
1: |Aldol Condensation;
DOI:10.1021/cs500667g
- Guidance literature:
-
Multi-step reaction with 2 steps
1: (5aR,10bS)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; caesium carbonate / tetrahydrofuran / 16 h / 20 °C / Molecular sieve
2: lithium aluminium tetrahydride / tetrahydrofuran / 0.17 h / -78 °C
With
(5aR,10bS)-5a,10b-dihydro-2-(2,4,6-trimethylphenyl)-4H,6H-indeno[2,1-b]-1,2,4-triazolo[4,3-d]-1,4-oxazinium chloride; lithium aluminium tetrahydride; caesium carbonate;
In
tetrahydrofuran;
DOI:10.1021/cs500667g
