N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide

Base Information

• Chemical Name: N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide
• CAS No.: 1262121-47-0
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• Mol file: 1262121-47-0.mol

Synonyms:N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide

Chemical Property of N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide

There total 1 articles about N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-acetyl,N-acetylphenylephrone (679395-42-7) → N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide (1262121-47-0)

Guidance literature:

O-acetyl,N-acetylphenylephrone; With water; potassium carbonate; at 50 ℃; for 1h;

With hydrogenchloride; In water; pH=6;

DOI:10.1016/j.tetasy.2010.09.013

Reference yield: 82.0%

N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide (1262121-47-0) → Phenylephrine (1477-63-0) + C11H15NO3 (1262121-49-2)

Guidance literature:

With C₆₅H₇₆Cl₂N₄O₆P₂Ru; hydrogen; potassium hydroxide; In water; isopropyl alcohol; at 63 ℃; for 3h; under 22502.3 - 23252.3 Torr; optical yield given as %ee; enantioselective reaction; Autoclave;

DOI:10.1016/j.tetasy.2010.09.013

Reference yield:

N-[2-(3-hydroxyphenyl)-2-oxo-ethyl]-N-methyl-acetamide (1262121-47-0) → C11H15NO3 (58952-80-0)

Guidance literature:

With RuCl₂[(S)-xylyl-2,2,6,6’-tetramethoxy-4,4’-bis(diphenylphosphino)-3,3-bipyridine][(R)-1,1-bis(4-methoxyphenyl)-3-methyl-1,2-butanediamine]; hydrogen; potassium hydroxide; In water; isopropyl alcohol; at 65 ℃; for 1.5h; under 21002.1 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1016/j.tetasy.2010.09.013

upstream raw materials:

O-acetyl,N-acetylphenylephrone

Downstream raw materials:

Phenylephrine

C₁₁H₁₅NO₃

C₁₁H₁₅NO₃

N-acetyl-1-(3-hydroxyphenyl)-2-methylaminoethanol

Refernces