(3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

Base Information

Chemical Name:(3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one
CAS No.:172484-39-8
Molecular Formula:C₂₆H₂₆O₈
Molecular Weight:466.488
Hs Code.:

Synonyms:(3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

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Chemical Property of (3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

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Technology Process of (3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

There total 6 articles about (3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: (3RS)-3-(3-benzyloxy-4-methoxyphenyl)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-1H-2-benzopyran-1-one

: 172484-39-8
(3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 6h; Ambient temperature;
DOI:10.1016/0957-4166(95)00367-X

Reference yield:

: 118842-88-9
(3-acetyloxy-2-ethoxycarbonylbenzyl)-triphenylphosphonium bromide

: 172484-39-8
(3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaOEt / 1.) EtOH, RT, 20 min, 2.) EtOH, reflux, 6 h

2: 98 percent / KOH / ethanol / 4 h / Heating

3: 91 percent / aq. CF₃COOH / CH₂Cl₂ / 12 h / Heating

4: 99 percent / pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 33 percent / H₂ / 5percent Pd/C / ethyl acetate / 6 h / Ambient temperature

With pyridine; potassium hydroxide; hydrogen; sodium ethanolate; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;
DOI:10.1016/0957-4166(95)00367-X

Reference yield:

: 66380-87-8
(+/-)-3-(3-benzyloxy-4-methoxyphenyl)-3,4-dihydro-8-hydroxy-1H-2-benzopyran-1-one

: 172484-39-8
(3R)-(+)-8-<(1R,4S)-camphanoyloxy>-3,4-dihydro-3-(3-hydroxy-4-methoxyphenyl)-1H-2-benzopyran-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / pyridine / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 33 percent / H₂ / 5percent Pd/C / ethyl acetate / 6 h / Ambient temperature

With pyridine; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1016/0957-4166(95)00367-X