4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Base Information

Chemical Name:4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide
CAS No.:1572927-52-6
Molecular Formula:C₁₈H₂₁N₅O₄S₂
Molecular Weight:435.528
Hs Code.:

Synonyms:4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

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Chemical Property of 4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

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Technology Process of 4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

There total 14 articles about 4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 1572928-08-5
tert-butyl (5-(((3S)-3-(1-propyn-1-yl)-4-(4-sulfamoylphenyl)-1-piperazinyl)sulfonyl)-2-pyridinyl)carbamate

: 1572927-52-6
4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃;
DOI:10.1021/jm5000497

Reference yield:

: 1450620-13-9
benzyl (3S)-3-(1-propyn-1-yl)-1-piperazinecarboxylate

: 1572927-52-6
4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium t-butanolate; johnphos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 4 h / 20 - 110 °C / Inert atmosphere

2: sulfuric acid / chloroform / 3 h / 0 °C

3: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With pyridine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sulfuric acid; trifluoroacetic acid; johnphos; sodium t-butanolate; In 1,4-dioxane; dichloromethane; chloroform;

Reference yield:

: 4214-76-0,67476-67-9
5-nitro-pyridin-2-ylamine

: 1572927-52-6
4-((2S)-4-((6-amino-3-pyridinyl)-sulfonyl)-2-(1-propyn-1-yl)-1-piperazinyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; dmap / dichloromethane / 18 h / 20 °C

2.1: ammonium chloride; zinc / tetrahydrofuran; methanol; water / 12 h / 20 °C

3.1: sodium nitrite; hydrogenchloride / water; acetonitrile / 0.5 h / 0 - 10 °C

3.2: 0.75 h / 0 °C

4.1: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 2 h / 0 - 20 °C

With pyridine; hydrogenchloride; dmap; ammonium chloride; triethylamine; trifluoroacetic acid; zinc; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;