2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide

Base Information

• Chemical Name: 2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide
• CAS No.: 1422169-92-3
• Molecular Formula: C₂₄H₁₉BrClNO₃
• Molecular Weight: 484.777

Synonyms:2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide

Chemical Property of 2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide

Chemical Property:

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Technology Process of 2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide

There total 1 articles about 2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

→ 2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide (1422169-92-3)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield: 17.8%

2-(2-bromobenzofuran-5-yl)-N-((4-chloro-2-methylphenyl)(phenyl)methyl)-2-hydroxyacetamide (1422169-92-3) + (2-methylpyridin-3-yl)boronic acid (899436-71-6) → C30H25ClN2O3 (1422167-08-5)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; at 90 ℃; for 3h; Inert atmosphere;

Downstream raw materials:

C₃₀H₂₅ClN₂O₃

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