{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester
CAS No.:745794-13-2
Molecular Formula:C₂₇H₃₄N₂O₆
Molecular Weight:482.577
Hs Code.:

Synonyms:{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

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Chemical Property of {(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

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Technology Process of {(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

There total 8 articles about {(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 745794-08-5
{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-hydroxymethyl-pent-4-enyl}-carbamic acid tert-butyl ester

: 745794-13-2
{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane;
DOI:10.1021/jo0496547

Reference yield:

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 745794-13-2
{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 8.1 g / MgSO₄ / CH₂Cl₂ / 20 °C

2: 87 percent / ZnBr₂ / tetrahydrofuran; diethyl ether / 4 h / -70 °C

3: Zn; Cu(OAc)2; AcOH / H₂O / 2 h / 70 °C

4: NaHCO₃ / H₂O; ethyl acetate / 20 °C

5: 8.64 g / p-TsOH*H₂O / methanol / 1 h / Heating

6: (COCl)2; DMSO; Et₃N / CH₂Cl₂

With copper diacetate; oxalyl dichloride; sodium hydrogencarbonate; magnesium sulfate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; zinc dibromide; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; 6: Swern oxidation;
DOI:10.1021/jo0496547

Reference yield:

: 108149-63-9
4-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

: 745794-13-2
{(1R,2S)-2-[Benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-1-formyl-pent-4-enyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 - 20 °C

2: 8.1 g / MgSO₄ / CH₂Cl₂ / 20 °C

3: 87 percent / ZnBr₂ / tetrahydrofuran; diethyl ether / 4 h / -70 °C

4: Zn; Cu(OAc)2; AcOH / H₂O / 2 h / 70 °C

5: NaHCO₃ / H₂O; ethyl acetate / 20 °C

6: 8.64 g / p-TsOH*H₂O / methanol / 1 h / Heating

7: (COCl)2; DMSO; Et₃N / CH₂Cl₂

With copper diacetate; oxalyl dichloride; sodium hydrogencarbonate; magnesium sulfate; toluene-4-sulfonic acid; acetic acid; dimethyl sulfoxide; triethylamine; zinc dibromide; zinc; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; 1: Swern oxidation / 7: Swern oxidation;
DOI:10.1021/jo0496547