2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide
CAS No.:1360537-73-0
Molecular Formula:C₂₄H₁₅F₂N₅O₃S
Molecular Weight:491.478
Hs Code.:

Synonyms:2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Property of 2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

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Technology Process of 2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

There total 11 articles about 2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1086062-66-9
GS⁽²⁶⁴⁾K₂₁₅₈

: 1360537-73-0
2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; for 4h; Reflux;
DOI:10.1016/j.bmcl.2011.12.136

Reference yield:

: 67443-38-3
5-bromo-2-chloro-3-nitropyridine

: 1360537-73-0
2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 0 - 20 °C

2: tin(II) chloride dihdyrate / ethyl acetate / 4 h / Reflux

3: pyridine / 0 - 20 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / Reflux

5: trimethylsilyl iodide / acetonitrile / 4 h / Reflux

With pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tin(II) chloride dihdyrate; trimethylsilyl iodide; sodium carbonate; In 1,4-dioxane; methanol; ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2011.12.136

Reference yield:

: 927801-23-8
6-bromo-4-iodoquinoline

: 1360537-73-0
2,4-difluoro-N-(2-hydroxy-5-(4-(pyridazin-4-yl)quinolin-6-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / Reflux

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / 1,4-dioxane / Reflux

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane / Reflux

4: trimethylsilyl iodide / acetonitrile / 4 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trimethylsilyl iodide; potassium acetate; sodium carbonate; In 1,4-dioxane; acetonitrile;
DOI:10.1016/j.bmcl.2011.12.136