(2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

Base Information

Chemical Name:(2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol
CAS No.:949077-07-0
Molecular Formula:C₃₀H₄₆O₄Si
Molecular Weight:498.778
Hs Code.:

Synonyms:(2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

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Chemical Property of (2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

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Technology Process of (2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

There total 7 articles about (2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 948995-09-3
(2'R,3'R,4R,4'E,9'R)-4-benzyl-3-[9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decenoyl]-2-oxazolidinone

: 949077-07-0
(2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; water; at 0 ℃; for 40h;
DOI:10.1021/jo0708442

Reference yield:

: 854612-90-1
(5R)-5-(t-butyldiphenylsilyloxy)hexanenitrile

: 949077-07-0
(2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1.1: DIBAL-H / toluene / 1.5 h / -78 °C

2.1: 2.01 g / benzene / 29.5 h

3.1: 99 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

4.1: 89 percent / MnO₂ / CH₂Cl₂ / 0.25 h / 0 °C

5.1: Bu₂BOTf / CH₂Cl₂ / 0.33 h / 0 °C

5.2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

5.3: 98 percent / CH₂Cl₂ / 4 h / -78 - 0 °C

6.1: 99 percent / i-Pr₂NEt / CH₂Cl₂ / 10 h / Heating

7.1: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 40 h / 0 °C

With manganese(IV) oxide; sodium tetrahydroborate; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; toluene; benzene;
DOI:10.1021/jo0708442

Reference yield:

: 855256-87-0
(5R)-5-[1-(tert-butyl)-1,1-diphenylsilyl]oxyhexanal

: 949077-07-0
(2S,3R,4E,9R)-9-(tert-butyldiphenylsilyloxy)-3-methoxymethoxy-2,4-dimethyl-4-decen-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: 2.01 g / benzene / 29.5 h

2.1: 99 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

3.1: 89 percent / MnO₂ / CH₂Cl₂ / 0.25 h / 0 °C

4.1: Bu₂BOTf / CH₂Cl₂ / 0.33 h / 0 °C

4.2: Et₃N / CH₂Cl₂ / 1 h / 0 °C

4.3: 98 percent / CH₂Cl₂ / 4 h / -78 - 0 °C

5.1: 99 percent / i-Pr₂NEt / CH₂Cl₂ / 10 h / Heating

6.1: 98 percent / NaBH₄ / tetrahydrofuran; H₂O / 40 h / 0 °C

With manganese(IV) oxide; sodium tetrahydroborate; di-n-butylboryl trifluoromethanesulfonate; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; benzene;
DOI:10.1021/jo0708442