N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

Base Information

Chemical Name:N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide
CAS No.:1426214-74-5
Molecular Formula:C₁₈H₁₂Cl₃N₃O₃S
Molecular Weight:456.737
Hs Code.:

Synonyms:N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

Suppliers and Price of N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

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Technology Process of N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

There total 5 articles about N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 912675-28-6
2,3-dichloro-N-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-benzenesulfonamide

: 136866-39-2
1-(3,5-dichloropyrazin-2-yl)ethan-1-one

: 1426214-74-5
N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,4-dioxane; water; at 100 ℃; for 2h;

Reference yield:

: 214360-73-3
4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)aniline

: 1426214-74-5
N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 h / 20 - 25 °C

2: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / 1,4-dioxane; water / 2 h / 100 °C

With pyridine; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;

Reference yield:

: 136866-27-8
3,5-dichloro-pyrazine-2-carbaldehyde

: 1426214-74-5
N-[4-(5-acetyl-6-chloro-pyrazin-2-yl)-phenyl]-2,3-dichloro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0.17 h / 5 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 0.5 h / 20 - 25 °C

3: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate / 1,4-dioxane; water / 2 h / 100 °C

With palladium bis[bis(diphenylphosphino)ferrocene] dichloride; caesium carbonate; Dess-Martin periodane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; 3: |Suzuki-Miyaura Coupling;