N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Base Information

Chemical Name:N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester
CAS No.:221345-68-2
Molecular Formula:C₃₈H₅₀N₄O₉
Molecular Weight:706.836
Hs Code.:

N-<(2R,3R)-1-<<N-(tert-butoxycarbonyl)-(S)-phenylalanyl>-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Synonyms:N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

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Chemical Property of N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

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Technology Process of N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

There total 4 articles about N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

: 221345-68-2
N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

2: 95 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr / Ambient temperature

3: 57 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

4: 1.) dicyclohexylcarbodiimide, 2.) 4-(dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 45 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 4 h

With dmap; diphenyl phosphoryl azide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm981061z

Reference yield:

: 167933-78-0
(2R,3R)-aziridine-2,3-dicarboxylic acid monoethyl ester

: 221345-68-2
N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 35 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

2: 95 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr / Ambient temperature

3: 57 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

4: 1.) dicyclohexylcarbodiimide, 2.) 4-(dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 45 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 4 h

With dmap; diphenyl phosphoryl azide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm981061z

Reference yield:

: 221345-60-4
N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

: 221345-68-2
N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr / Ambient temperature

2: 57 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

3: 1.) dicyclohexylcarbodiimide, 2.) 4-(dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 45 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 4 h

With dmap; diphenyl phosphoryl azide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm981061z