2H-1,2,3-Triazole-4-carboxylicacid,2-methyl-,methylester(9CI)

Base Information

• Chemical Name: 2H-1,2,3-Triazole-4-carboxylicacid,2-methyl-,methylester(9CI)
• CAS No.: 105020-39-1
• Molecular Formula: C₅H₇N₃O₂
• Molecular Weight: 141.129
• Hs Code.: 2933990090
• Mol file: 105020-39-1.mol

Synonyms:2-Methyl-2H-[1,2,3]triazole-4-carboxylicacid methyl ester; Methyl 2-methyl-2H-1,2,3-triazole-4-carboxylate

Chemical Property of 2H-1,2,3-Triazole-4-carboxylicacid,2-methyl-,methylester(9CI)

Chemical Property:

• Refractive Index: 1.57
• PSA: 57.01000
• LogP: -0.39830
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Methyl2-Methyl-1,2,3-triazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2H-1,2,3-Triazole-4-carboxylicacid,2-methyl-,methylester(9CI)

There total 13 articles about 2H-1,2,3-Triazole-4-carboxylicacid,2-methyl-,methylester(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

diazomethane (24153-51-3,175791-16-9,353495-36-0,6843-83-0) + trans-4,5-Dicyan-4,5-dihydro-1H-pyrazol-4,5-dicarbonsaeure-dimethylester (105020-40-4) → methyl 1-methyl-1H-1,2,3-triazole-5-carboxylate (105020-38-0) + 2-Methyl-1,2,3-triazol-4-carbonsaeure-methylester (105020-39-1) + 4-Cyan-1-methyl-3-pyrazolcarbonsaeure-methylester (105020-37-9) + 4-Cyan-1-methyl-5-pyrazolcarbonsaeure-methylester (70910-18-8)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 26h; Further byproducts given;

DOI:10.3987/R-1986-09-2429

Reference yield: 78.0%

diazomethane (24153-51-3,175791-16-9,353495-36-0,6843-83-0) + trans-4,5-Dicyan-4,5-dihydro-1H-pyrazol-4,5-dicarbonsaeure-dimethylester (105020-40-4) → methyl 1-methyl-1H-1,2,3-triazole-5-carboxylate (105020-38-0) + 2-Methyl-1,2,3-triazol-4-carbonsaeure-methylester (105020-39-1) + 4-Cyan-1-methyl-5-pyrazolcarbonsaeure-methylester (70910-18-8) + 1-Methyl-1,2,3-triazol-4-carbonsaeure-methylester (57362-82-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 26h;

DOI:10.3987/R-1986-09-2429

Reference yield: 78.0%

diazomethane (24153-51-3,175791-16-9,353495-36-0,6843-83-0) + trans-4,5-Dicyan-4,5-dihydro-1H-pyrazol-4,5-dicarbonsaeure-dimethylester (105020-40-4) → 2-Methyl-1,2,3-triazol-4-carbonsaeure-methylester (105020-39-1) + 4-Cyan-1-methyl-3-pyrazolcarbonsaeure-methylester (105020-37-9) + 4-Cyan-1-methyl-5-pyrazolcarbonsaeure-methylester (70910-18-8) + 1-Methyl-1,2,3-triazol-4-carbonsaeure-methylester (57362-82-0)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 26h;

DOI:10.3987/R-1986-09-2429

upstream raw materials:

diazomethane

methyl cyanoformate

dimethyl 2,3-dicyanofumarate

diazomethane

Refernces

• 1、 Prabakaran,Khan, Fazlur-Rahman Nawaz,Jin, Jong Sung. "ZnO nanoparticles-mediated regioselective synthesis of methyl-iV-alkylated 1,2,3-triazole-4-carboxylates". experimental part. p. 1101 - 1109. Retrieved 2012/08/28.
• 2、 -. "HEPATITIS C INHIBITOR COMPOUNDS". Page/Page column 33. . Retrieved 2011/06/23.