TD 139

Base Information

• Chemical Name: TD 139
• CAS No.: 1450824-22-2
• Molecular Formula: C₂₈H₃₀F₂N₆O₈S
• Molecular Weight: 648.644

Synonyms:(2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-sulfanylbis(4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol)

Chemical Property of TD 139

Chemical Property:

• Boiling Point: 1017.2±75.0 °C(Predicted)
• PKA: 12.33±0.70(Predicted)
• Density: 1.76±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

TD139 >98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: TD 139 is used as a galactoside inhibitors of galectins, suitable for treating pulmonary fibrosis; such as idiopathic pulmonary fibrosis in mammals.

Technology Process of TD 139

There total 35 articles about TD 139 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2S,2'S,3R,3'R,4S,4'S,5R,5'R,6R,6'R)-sulfanylbis(5-acetoxy-6-(acetoxymethyl)-4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)tetrahydro-2H-pyran-2,3-diyl) dibenzoate → (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-sulfanylbis(4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol) (1450824-22-2)

Guidance literature:

With methanol; sodium methylate; In dichloromethane; at 20 ℃; for 4h;

Reference yield: 84.0%

2,2’,4,4’,6,6’-hexa-O-acetyl-3,3’-dideoxy-3,3’-bis-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1,1‘-sulfanediyl-di-β-D-galactopyranoside → (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-sulfanylbis(4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol) (1450824-22-2)

Guidance literature:

With methanol; sodium methylate; In acetonitrile; at 20 ℃; for 0.5h; Large scale;

Reference yield: 76.0%

bis-(3-azido-3-deoxy-β-D-galactopyranosyl)-sulfane (1193784-39-2) + 1-ethynyl-3-fluoro-benzene (2561-17-3) → (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-sulfanylbis(4-(4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,5-diol) (1450824-22-2)

Guidance literature:

With copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

phenyl 4,6-O-benzylidene-1-thio-β-D-galactopyranoside

phenyl 2-O-acetyl-4,6-O-benzylidene-1-thio-3-O-trifluoromethanesulfonyl-β-D-galactopyranoside

phenyl 2-O-acetyl-4,6-O-benzylidene-1-thio-3-O-trifluoromethanesulfonyl-β-D-gulopyranoside

phenyl 2-O-acetyl-3-azido-4,6-O-benzylidene-3-deoxy-1-thio-β-D-galactopyranoside

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