Technology Process of dimethyl[3,5-bis(trifluoromethyl)phenyl][(E)-4-bromostyryl]silane
There total 1 articles about dimethyl[3,5-bis(trifluoromethyl)phenyl][(E)-4-bromostyryl]silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II);
In
dichloromethane;
at 20 ℃;
for 1.5h;
DOI:10.1021/jo052602c
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
bis(η3-allyl-μ-chloropalladium(II));
In
tetrahydrofuran;
at 20 ℃;
for 10h;
DOI:10.1021/jo052602c
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 75 percent / TBAF*3H2O / [Pd(η3-allyl)(μ-Cl)]2 / tetrahydrofuran / 10 h / 20 °C
2: 97 percent / NEt3; CuI / PdCl2(PPh3)2 / 17 h / 60 °C
3: 100 percent / KOH / methanol; tetrahydrofuran; H2O / 2 h / 20 °C
4: 98 percent / Ru(H)Cl(CO)(PPh3)3 / CH2Cl2 / 1 h / 20 °C
5: 57 percent / TBAF*3H2O / [Pd(η3-allyl)(μ-Cl)]2 / tetrahydrofuran / 15 h / 20 °C
With
potassium hydroxide; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine;
bis-triphenylphosphine-palladium(II) chloride; (carbonyl)(chloro)(hydrido)tris(triphenylphosphine)ruthenium(II); bis(η3-allyl-μ-chloropalladium(II));
In
tetrahydrofuran; methanol; dichloromethane; water;
1: Hiyama coupling / 2: Sonogashira coupling / 5: Hiyama coupling;
DOI:10.1021/jo052602c
