(2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

Base Information

Chemical Name:(2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone
CAS No.:245073-31-8
Molecular Formula:C₂₄H₃₄O₄Si
Molecular Weight:414.617
Hs Code.:

Synonyms:(2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

Suppliers and Price of (2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

Chemical Property:

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Technology Process of (2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

There total 3 articles about (2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 245073-29-4
2-(tert-butyl-dimethyl-silanyloxy)-6-(tert-butyl-diphenyl-silanyloxy)-5-hydroxy-4-methyl-heptan-3-one

: 245073-31-8
(2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

Guidance literature:: With hydrogen fluoride; In acetonitrile;
DOI:10.1016/S0040-4039(99)00987-9

Reference yield:

: 87696-33-1
(S)-2-(O-tert-butyldiphenylsilyloxy)propanal

: 245073-31-8
(2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride; diisopropylethylamine / CH₂Cl₂ / -78 °C

2: 84 percent / HF / acetonitrile; H₂O / 0.75 h / 20 °C

With hydrogen fluoride; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile; 1: aldol reaction;
DOI:10.1016/j.tet.2006.09.034

Reference yield:

: 187590-50-7
(S) 4-(tert-butyldimethylsilyloxy)-3-pentanone

: 245073-31-8
(2S,4R,5R,6S)-6-tert-butyldiphenylsilyloxy-2,5-dihydroxy-4-methyl-3-pentanone

Guidance literature:: Multi-step reaction with 2 steps

1: titanium tetrachloride; diisopropylethylamine / CH₂Cl₂ / -78 °C

2: 84 percent / HF / acetonitrile; H₂O / 0.75 h / 20 °C

With hydrogen fluoride; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile; 1: aldol reaction;
DOI:10.1016/j.tet.2006.09.034