tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate
CAS No.:1036990-37-0
Molecular Formula:C₂₃H₃₅BN₂O₅
Molecular Weight:430.352
Hs Code.:

Synonyms:tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

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Chemical Property of tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

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Technology Process of tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

There total 1 articles about tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.8%

: 269409-73-6
3-carboxyphenylboronic acid pinacol ester

: 112275-50-0
tert-butyl 1,4-diazepine-1-carboxylate

: 1036990-37-0
tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1415314-10-1
8-bromo-6-iodo-[1,2,4]triazolo[1,5-a]pyridine

: 1036990-37-0
tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

: 1415695-10-1
tert-butyl 4-(3-(8-bromo-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzoyl)-1,4-diazepane-1-carboxylate

Guidance literature:: With water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 20 - 95 ℃; for 24.16h; Inert atmosphere;

Reference yield:

: 1036990-37-0
tert-butyl 4-(-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)-1,4-diazepane-1-carboxylate

: 1415695-11-2
tert-butyl 4-(3-(8-(5,6-dimethoxypyridin-2-ylamino)-[1,2,4]-triazolo[1,5-a]pyridin-6-yl)benzoyl)-1,4-diazepane-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 24.16 h / 20 - 95 °C / Inert atmosphere

2: caesium carbonate; XPhos / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 24.16 h / 20 - 95 °C / Inert atmosphere

With water; sodium carbonate; caesium carbonate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane;