diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Base Information

Chemical Name:diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate
CAS No.:149359-31-9
Molecular Formula:C₄₆H₆₀NO₁₆P
Molecular Weight:913.953
Hs Code.:

Synonyms:diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Suppliers and Price of diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

There total 8 articles about diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 108-24-7
acetic anhydride

: 149359-30-8
diethyl (3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

: 149359-31-9
diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Guidance literature:: diethyl (3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate; With hydrazine hydrate; In ethanol; water; at 80 ℃; for 1.5h;

acetic anhydride; With pyridine; for 12h;
DOI:10.1016/j.bmc.2004.09.019

Reference yield:

: 7772-87-4
3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-β-D-glucopyranosyl chloride

: 149359-31-9
diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 83 percent / silver(I) trifluoromethanesulfonate; collidine; molecular sieves 4 Angstroem / CH₂Cl₂ / -30 - 20 °C

2.1: hydrazine hydrate / ethanol; H₂O / 1.5 h / 80 °C

2.2: 88 percent / pyridine / 12 h

With 2,3,5-trimethyl-pyridine; 4 A molecular sieve; silver trifluoromethanesulfonate; hydrazine hydrate; In ethanol; dichloromethane; water;
DOI:10.1016/j.bmc.2004.09.019

Reference yield:

: 149359-29-5
(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methyl iodide

: 149359-31-9
diethyl (2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl-(1->4)-2,3,6-tri-O-benzyl-α-D-glucopyranosyl)methylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 53 percent / 9.5 h / Heating

2.1: 83 percent / silver(I) trifluoromethanesulfonate; collidine; molecular sieves 4 Angstroem / CH₂Cl₂ / -30 - 20 °C

3.1: hydrazine hydrate / ethanol; H₂O / 1.5 h / 80 °C

3.2: 88 percent / pyridine / 12 h

With 2,3,5-trimethyl-pyridine; 4 A molecular sieve; silver trifluoromethanesulfonate; hydrazine hydrate; In ethanol; dichloromethane; water; 1.1: Arbuzov reaction;
DOI:10.1016/j.bmc.2004.09.019