malonic acid mono-(4-methoxy-phenyl) ester

Base Information

• Chemical Name: malonic acid mono-(4-methoxy-phenyl) ester
• CAS No.: 58303-20-1
• Molecular Formula: C₁₀H₁₀O₅
• Molecular Weight: 210.186
• Mol file: 58303-20-1.mol

Synonyms:malonic acid mono-(4-methoxy-phenyl) ester

Chemical Property of malonic acid mono-(4-methoxy-phenyl) ester

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of malonic acid mono-(4-methoxy-phenyl) ester

There total 2 articles about malonic acid mono-(4-methoxy-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cycl-isopropylidene malonate (2033-24-1) + 4-methoxy-phenol (150-76-5) → malonic acid mono-(4-methoxy-phenyl) ester (58303-20-1)

Guidance literature:

In toluene; at 110 ℃; for 4h;

DOI:10.1021/acs.jmedchem.0c00602

Reference yield: 61.0%

malonic acid monochloride (51932-41-3) + 4-methoxy-phenol (150-76-5) → malonic acid mono-(4-methoxy-phenyl) ester (58303-20-1)

Guidance literature:

In neat (no solvent); at 100 ℃; for 0.0333333h;

DOI:10.1021/ol400804b

Reference yield: 90.0%

malonic acid mono-(4-methoxy-phenyl) ester (58303-20-1) + methyl 2-O-methoxymethyl-4,6-O-benzylidene-β-D-galactopyranoside → methyl 4,6-di-O-benzylidene-2-O-methoxymethyl-3-O-[(3'-O-{4-methoxyphenyl})malonyl]-β-D-galactopyranoside

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at -20 - 20 ℃;

DOI:10.1021/acs.jmedchem.0c00602

upstream raw materials:

malonic acid monochloride

4-methoxy-phenol

cycl-isopropylidene malonate

Downstream raw materials:

2-hydroxy-2-methyl-succinic acid 1-ethyl ester 4-(4-methoxy-phenyl) ester

4-hydroxy-6-methoxycoumarin