R-(-)-Indeloxazine

Base Information

• Chemical Name: R-(-)-Indeloxazine
• CAS No.: 104908-33-0
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 104908-33-0.mol

Synonyms:Morpholine,2-[(1H-inden-7-yloxy)methyl]-, (R)- (9CI); R-(-)-Indeloxazine

Chemical Property of R-(-)-Indeloxazine

Chemical Property:

• PSA: 0.00000
• LogP: 0.00000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of R-(-)-Indeloxazine

There total 5 articles about R-(-)-Indeloxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.1%

4-morpholin-2-ylmethoxy-indan-1-ol (60929-60-4) → indeloxazine (60929-23-9,104908-33-0) + (+/-)-2-<(inden-4-yloxy)methyl>morpholine (60929-22-8)

Guidance literature:

In methanol; chloroform; toluene;

Reference yield:

6-(3H-Inden-4-yloxymethyl)-morpholin-3-one (104908-23-8) → indeloxazine (60929-23-9,104908-33-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Yield given;

DOI:10.1248/cpb.33.3766

Reference yield:

1-Amino-3-(3H-inden-4-yloxy)-propan-2-ol (81542-44-1) → indeloxazine (60929-23-9,104908-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂

2: MeONa / methanol

3: LiAlH₄ / tetrahydrofuran

With lithium aluminium tetrahydride; sodium methylate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1248/cpb.33.3766

upstream raw materials:

6-(3H-Inden-4-yloxymethyl)-morpholin-3-one

1-Amino-3-(3H-inden-4-yloxy)-propan-2-ol

4-morpholin-2-ylmethoxy-indan-1-ol

Refernces

• 1、 -. "2-(Indenyloxymethyl) morpholine derivatives". . . Retrieved 2008/06/13.