N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine
• CAS No.: 1356010-51-9
• Molecular Formula: C₂₈H₂₇F₂N₇O
• Molecular Weight: 515.565

Synonyms:N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property of N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine

There total 6 articles about N₄-allyl-N₂-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (1356009-07-8) + N-allyl-2-chloro-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amine (1356009-93-2) → N4-allyl-N2-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-51-9)

Guidance literature:

at 150 ℃; for 0.75h;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → N4-allyl-N2-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-51-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / dimethyl sulfoxide / 48 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

2.2: 0.5 h / 20 °C

3.1: ammonium chloride; iron / methanol / 0.83 h / 65 °C

4.1: 0.75 h / 150 °C

With iron; sodium hydride; sodium hydrogencarbonate; ammonium chloride; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

1-(2-Fluoro-4-nitro-phenyl)-3-methyl-1H-[1,2,4]triazole → N4-allyl-N2-(3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine-2,4-diamine (1356010-51-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 °C

1.2: 0.5 h / 20 °C

2.1: ammonium chloride; iron / methanol / 0.83 h / 65 °C

3.1: 0.75 h / 150 °C

With iron; sodium hydride; ammonium chloride; In methanol; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

3,4-difluoronitrobenzene

7-(2,4-difluorophenyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidine-2,4(3H,5H)-dione

2,4-dichloro-7-(2,4-difluorophenyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidine

3-(allyloxy)-4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline

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