Technology Process of (E)-ethyl 6-bromo-5-phenylhex-2-enoate
There total 3 articles about (E)-ethyl 6-bromo-5-phenylhex-2-enoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: diisobutylaluminium hydride / dichloromethane / 6 h / -78 °C
2: dichloromethane / 22 h / 20 °C / Inert atmosphere
3: carbon tetrabromide; triphenylphosphine / 0.5 h / 0 - 20 °C
With
carbon tetrabromide; diisobutylaluminium hydride; triphenylphosphine;
In
dichloromethane;
2: Wittig olefination;
DOI:10.1021/ol301044e
- Guidance literature:
-
With
carbon tetrabromide; triphenylphosphine;
at 0 - 20 ℃;
for 0.5h;
optical yield given as %de;
DOI:10.1021/ol301044e
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dichloromethane / 22 h / 20 °C / Inert atmosphere
2: carbon tetrabromide; triphenylphosphine / 0.5 h / 0 - 20 °C
With
carbon tetrabromide; triphenylphosphine;
In
dichloromethane;
1: Wittig olefination;
DOI:10.1021/ol301044e
