2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

Base Information

Chemical Name:2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile
CAS No.:167159-33-3
Molecular Formula:C₃₁H₃₆N₂O₄S
Molecular Weight:532.704
Hs Code.:

2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-<i>p</i>-tolylsulfanyl-heptanenitrile

Synonyms:2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

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Chemical Property of 2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

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Technology Process of 2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

There total 8 articles about 2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 167159-82-2
2,3-dihydro-6-methoxy-1H-isoindol-5-ol

: 167159-64-0
α-(5-chloropentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile

: 167159-33-3
2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium iodide; In acetonitrile; Heating;
DOI:10.1021/jm9804477

Reference yield:

: 835-79-0
1-(benzyloxy)-2-methoxybenzene

: 167159-33-3
2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 8 percent / ZnI₂, HCl(g) / diethyl ether / 3 h / 25 °C

2: 67 percent / 10 N NaOH, n-tertbutylammonium chloride / toluene / 48 h / 25 °C

3: 87 percent / H₂ / 35 percent Pd(OH)2/C / ethanol / 21 h / 2585.74 Torr / Ambient temperature

4: 74 percent / diisopropylethylamine, NaI / acetonitrile / Heating

With hydrogenchloride; sodium hydroxide; n-tertbutylammonium chloride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; zinc(II) iodide; palladium dihydroxide; In diethyl ether; ethanol; toluene; acetonitrile;
DOI:10.1021/jm9804477

Reference yield:

: 167159-76-4
1,2-bis(chloromethyl)-4-methoxy-5-(phenylmethoxy)benzene

: 167159-33-3
2-(3,4-dimethoxy-phenyl)-7-(5-hydroxy-6-methoxy-1,3-dihydro-isoindol-2-yl)-2-p-tolylsulfanyl-heptanenitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / 10 N NaOH, n-tertbutylammonium chloride / toluene / 48 h / 25 °C

2: 87 percent / H₂ / 35 percent Pd(OH)2/C / ethanol / 21 h / 2585.74 Torr / Ambient temperature

3: 74 percent / diisopropylethylamine, NaI / acetonitrile / Heating

With sodium hydroxide; n-tertbutylammonium chloride; hydrogen; N-ethyl-N,N-diisopropylamine; sodium iodide; palladium dihydroxide; In ethanol; toluene; acetonitrile;
DOI:10.1021/jm9804477