5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

Base Information

Chemical Name:5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine
CAS No.:1279104-44-7
Molecular Formula:C₂₂H₁₆F₂N₆
Molecular Weight:402.406
Hs Code.:

Synonyms:5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

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Chemical Property of 5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

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Technology Process of 5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

There total 8 articles about 5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1279106-88-5
5-{5-[1-Benzenesulfonyl-2-(2,6-difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

: 1279104-44-7
5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

Guidance literature:: With methanol; caesium carbonate; In tetrahydrofuran; at 25 ℃; for 24h;

Reference yield:

: 13670-99-0
2,6-difluoroacetophenone

: 1279104-44-7
5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium acetate / ethanol / 16 h / 25 °C

2.1: polyphosphoric acid / 2 h / 130 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 25 °C

4.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6.1: sodium nitrite / sulfuric acid / water; acetonitrile / 0.5 h / Cooling with ice

6.2: 0.5 h / 0 °C

7.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

8.1: methanol; caesium carbonate / tetrahydrofuran / 24 h / 25 °C

With methanol; potassium acetate; sodium hydride; potassium carbonate; caesium carbonate; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1188072-92-5
5-bromo-2-(2,6-difluoro-phenyl)-1H-indole

: 1279104-44-7
5-{5-[2-(2,6-Difluoro-phenyl)-1H-indol-5-yl]-1-methyl-1H-pyrazol-3-yl}-pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0 - 25 °C

2.1: potassium carbonate / 1,4-dioxane / 25 - 110 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

4.1: sodium nitrite / sulfuric acid / water; acetonitrile / 0.5 h / Cooling with ice

4.2: 0.5 h / 0 °C

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 100 °C / Inert atmosphere

6.1: methanol; caesium carbonate / tetrahydrofuran / 24 h / 25 °C

With methanol; sodium hydride; potassium carbonate; caesium carbonate; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sulfuric acid; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetonitrile;