8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

Base Information

Chemical Name:8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one
CAS No.:1274848-49-5
Molecular Formula:C₁₈H₁₄N₂O₃
Molecular Weight:306.321
Hs Code.:

Synonyms:8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

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Chemical Property of 8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

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Technology Process of 8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

There total 6 articles about 8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1274848-28-0
6-methyl-8-((3-nitrophenyl)ethynyl)-2,3-dihydroquinolin-4(1H)-one

: 1274848-49-5
8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

Guidance literature:: With palladium dichloride; In acetonitrile; at 70 - 80 ℃; for 4h;
DOI:10.1039/c0ob00771d

Reference yield:

: 36054-00-9
6-methyl-2,3-dihydroquinolin-4(1H)-one

: 1274848-49-5
8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: Iodine monochloride; calcium carbonate / methanol; water / 2 h / 0 - 20 °C

2.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere

2.2: 6 h / 80 °C / Inert atmosphere

3.1: palladium dichloride / acetonitrile / 4 h / 70 - 80 °C

With copper(l) iodide; palladium 10% on activated carbon; Iodine monochloride; triethylamine; triphenylphosphine; calcium carbonate; palladium dichloride; In methanol; ethanol; water; acetonitrile; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d

Reference yield:

: 1274848-15-5
8-iodo-6-methyl-2,3-dihydroquinolin-4(1H)-one

: 1274848-49-5
8-methyl-5-(3-nitrophenyl)-2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine / ethanol / 1 h / 25 °C / Inert atmosphere

1.2: 6 h / 80 °C / Inert atmosphere

2.1: palladium dichloride / acetonitrile / 4 h / 70 - 80 °C

With copper(l) iodide; palladium 10% on activated carbon; triethylamine; triphenylphosphine; palladium dichloride; In ethanol; acetonitrile; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1039/c0ob00771d